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The KIR and CD94/NKG2 families of molecules in the rhesus monkey
Author(s) -
LaBonte Michelle L.,
Hershberger Karen L.,
Korber Bette,
Letvin Norman L.
Publication year - 2001
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2001.1830103.x
Subject(s) - biology , major histocompatibility complex , mhc class i , receptor , human leukocyte antigen , mhc restriction , natural killer cell , microbiology and biotechnology , immunology , genetics , antigen , cytotoxic t cell , in vitro
Summary: Natural killer (NK) cells and a subset of T cells express families of receptors that are capable of detecting major histocompatibility complex (MHC) class I expression on the surface of cells. Molecules of the killer cell immunoglobulin‐like receptor (KIR) family bind directly to MHC class I, while those of the CD94/NKG2 family recognize MHC class I signal sequences bound to HLA‐E. Both the KIR and CD94/NKG2 families are composed of activating and inhibitory molecules that serve to regulate the function of NK cells as a result of their MHC class I recognition. Here we review the recently described KIR and CD94/NKG2 family members in the rhesus monkey.