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Immunologic tolerance maintained by CD25 + CD4 + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance
Author(s) -
Sakaguchi Shimon,
Sakaguchi Noriko,
Shimizu Jun,
Yamazaki Sayuri,
Sakihama Toshiko,
Itoh Misako,
Kuniyasu Yuhshi,
Nomura Takashi,
Toda Masaaki,
Takahashi Takeshi
Publication year - 2001
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2001.1820102.x
Subject(s) - il 2 receptor , autoimmunity , immunology , biology , transplantation , immune tolerance , immunity , population , clonal deletion , immune system , t cell , antigen , microbiology and biotechnology , t cell receptor , medicine , environmental health
Summary: There is accumulating evidence that T‐cell‐mediated dominant control of self‐reactive T‐cells contributes to the maintenance of immunologic self‐tolerance and its alteration can cause autoimmune disease. Efforts to delineate such a regulatory T‐cell population have revealed that CD25 + cells in the CD4 + population in normal naive animals bear the ability to prevent autoimmune disease in vivo and, upon antigenic stimulation, suppress the activation/proliferation of other T cells in vitro . The CD25 + CD4 + regulatory T cells, which are naturally anergic and suppressive, appear to be produced by the normal thymus as a functionally distinct subpopulation of T cells. They play critical roles not only in preventing autoimmunity but also in controlling tumor immunity and transplantation tolerance.