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Human blood platelet gC1qR/p33
Author(s) -
Peerschke Ellinor I. B.,
Ghebrehiwet Berhane
Publication year - 2001
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2001.1800105.x
Subject(s) - platelet , biology , immunology , computational biology
Summary: Platelets are involved in the development of many types of vascular lesions. In addition to their role in primary hemostasis, they participate in inflammatory processes that may contribute to the development of thrombosis, atherosclerosis and vasculitis. In this regard, we have been interested in platelet interactions with the complement subcomponent C1q. C1q has been shown to modulate platelet interactions with collagen and immune complexes, and has been identified at sites of vascular injury and inflammation, as well as in atherosclerotic lesions. Platelets express a variety of C1q binding sites, including gC1qR/p33 (gC1qR), a multifunctional, multicompartment cellular protein. Here we focus on the structure and function of platelet gC1qR and its emerging role in modulating platelet function at sites of vascular injury and inflammation. The authors are grateful to Wei‐Xing Guo M.D. for construction of the Exon 2 expression vector and GST‐E2 fusion protein expression, and to Yan Fang and Tara K. Murphy for technical assistance. This research was supported in part by grant HL50291 from the National Heart Lung and Blood Institute (EIBP, BG) and grant IM771 (BG) from the American Cancer Society.