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The role of chemokines in human immunodeficiency virus infection
Author(s) -
GarzinoDemo Alfredo,
DeVico Anthony L.,
Conant Katherine E.,
Gallo Robert C.
Publication year - 2000
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2000.17711.x
Subject(s) - chemokine , immunology , biology , human immunodeficiency virus (hiv) , humoral immunity , immune system , immunity , innate immune system , chemokine receptor , virus , virology , immunopathology
Chemokines that bind to human immunodeficiency virus (HIV) co-receptors are potent and selective inhibitors of HIV infection. Therefore, ever since our discovery of this activity, we have proposed their role in controlling HIV infection as a third arm of the immune response, i.e. in concert with humoral and cellular responses. Research carried out in our laboratory, and performed independently by other groups, has recently strengthened this concept. Here, we critically analyze the evidence indicating the positive contribution of chemokines to HIV infection, their involvement with cognate and innate immunity, and the potential for their use in combating HIV infection.