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Follicular stromal cells and lymphocyte homing to follicles
Author(s) -
J G Cyster,
K M Ansel,
K Reif,
E H Ekland,
P L Hyman,
H L Tang,
S A Luther,
V N Ngo
Publication year - 2000
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2000.00618.x
Subject(s) - cxcl13 , germinal center , cxcr5 , follicular dendritic cells , stromal cell , biology , chemokine , homing (biology) , lymphocyte homing receptor , immunology , b cell , lymphocyte , follicular phase , microbiology and biotechnology , antigen , t cell , antigen presenting cell , chemokine receptor , cell , antibody , immune system , cancer research , endocrinology , cell adhesion , ecology , genetics
Follicular dendritic cells (FDCs), the best defined stromal cell subset within lymphoid follicles, play a critical role in presenting intact antigen to B lymphocytes. The discovery that many follicular stromal cells make B-lymphocyte chemoattractant (BLC), a CXC chemokine that attracts CXCR5+ cells, provides a basis for understanding how motile B cells come into contact with stationary FDCs. Here we review our work on BLC and discuss properties of BLC-expressing follicular stromal cells. We also review the properties of primary follicle and germinal center FDCs and suggest a model of FDC development that incorporates information about BLC expression. Finally, we consider how antigen recognition causes T and B lymphocytes to undergo changes in chemokine responsiveness that may help direct their movements into, or out of, lymphoid follicles.