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Time course of ultraviolet B‐induced erythema in people with red hair harbouring homozygous melanocortin 1 receptor mutations
Author(s) -
Ha Thomas K. K.,
Waterston Karen,
Bisset Yvonne,
Ray Amanda,
Rees Jonathan L.
Publication year - 2003
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1034/j.1600-0625.2003.00076.x
Subject(s) - erythema , melanocortin 1 receptor , dermatology , melanocortin , ultraviolet radiation , ultraviolet b , medicine , phenotype , receptor , skin cancer , biology , cancer , genetics , chemistry , gene , radiochemistry
It has previously been reported that the time course of erythema may be delayed in those with sun‐sensitive skin types and those with skin cancer. One molecular explanation for this putative phenotype would be that it is caused by mutations of the melanocortin 1 receptor (MC1R). In the present study of 20 persons, 10 of whom were MC1R homozygous, we measured erythema over a 21‐day period in response to a range of ultraviolet B doses using methods that improved on previous studies. We could detect no consistent differences in ultraviolet radiation‐induced erythema between the groups studied. The pharmacological mechanisms underpinning such prolonged inflammatory responses merit further investigation.