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Expression of angiogenic factors in neurofibromas
Author(s) -
Kawachi Yasuhiro,
Xu Xuezhu,
Ichikawa Eiko,
Imakado Sumihisa,
Otsuka Fujio
Publication year - 2003
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1034/j.1600-0625.2003.00062.x
Subject(s) - basic fibroblast growth factor , neurofibroma , angiogenesis , vascular endothelial growth factor , fibroblast growth factor receptor 3 , vascular endothelial growth factor c , hepatocyte growth factor , fibroblast growth factor , hypervascularity , vascular endothelial growth factor b , growth factor , fibroblast growth factor receptor 4 , fibroblast growth factor receptor 2 , midkine , cancer research , immunohistochemistry , biology , fibroblast , pathology , vascular endothelial growth factor a , fibroblast growth factor receptor , neurofibromatosis , medicine , immunology , vegf receptors , cell culture , genetics , receptor
We studied the expression of angiogenic factors (vascular endothelial growth factor, basic fibroblast growth factor, platelet‐derived growth factor and hepatocyte growth factor) in cutaneous neurofibroma samples from patients with neurofibromatosis‐1. Immunohistochemical staining and the reverse transcribed polymerase chain reaction (RT‐PCR) method demonstrated that vascular endothelial and basic fibroblast growths factor are highly expressed in neurofibroma cells at both the protein and mRNA level. These data suggest that vascular endothelial and basic fibroblast growth factors may contribute to both the angiogenesis and hypervascularity of neurofibromas.