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Biological effects of glycolic acid on dermal matrix metabolism mediated by dermal fibroblasts and epidermal keratinocytes
Author(s) -
Okano Yuri,
Abe Yumiko,
Masaki Hitoshi,
Santhanam Uma,
Ichihashi Masamitsu,
Funasaka Yoko
Publication year - 2003
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1034/j.1600-0625.12.s2.9.x
Subject(s) - glycolic acid , keratinocyte , chemistry , fibroblast , in vitro , matrix (chemical analysis) , microbiology and biotechnology , ex vivo , in vivo , dermis , cell , cancer research , biochemistry , biology , medicine , pathology , lactic acid , genetics , chromatography , bacteria
Glycolic acid (GA), one of the α‐hydroxy acids, is widely used as an agent for chemical peeling. Although there are several reports about the clinical effects of GA in the literature, its biological mechanism remains mostly unclear, and there are only a few reports about its effects on skin rejuvenation mediated by keratinocytes. The aim of this study was to investigate the effect of GA on the dermal matrix metabolism of keratinocytes and fibroblasts using in vitro and ex vivo systems. Our study shows that GA not only directly accelerates collagen synthesis by fibroblasts, but it also modulates matrix degradation and collagen synthesis through keratinocyte‐released cytokines. We confirm that IL‐1α is one of the primary mediators for matrix degradation released from keratinocytes after GA treatment. These results suggest that GA contributes to the recovery of photodamaged skin through various actions, depending on the skin cell type.