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Photoaging and oxidative stress
Author(s) -
Nishigori Chikako,
Hattori Yukari,
Arima Yaeno,
Miyachi Yoshiki
Publication year - 2003
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1034/j.1600-0625.12.s2.3.x
Subject(s) - photoaging , oxidative stress , ultraviolet radiation , dermatology , chemistry , skin aging , medicine , biochemistry , radiochemistry
Photoaging is significantly different from chronological aging in both clinical and histological appearance. It has been suggested that oxidative stress, generated by ultraviolet radiation (UVR), leads to photoaging over a long period. The presence of 8‐OHdG, and oxidatively modified proteins such as 4‐hydroxy‐2‐nonenal‐modified protein, 3‐ l ‐nitro‐tyrosine and N –ε (carboxymethyl)lysine in UV‐exposed skin specimens, supports this theory. The pathophysiology of photoaging of the skin caused by chronic inflammation after UVR is reviewed and discussed, with a focus on oxidative stress.