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Multilobated nuclei in Waldenström’ macroglobulinaemia
Author(s) -
Metzgeroth G.,
Sick Ch.,
Maywald O.,
Schatz M.,
Kuhn Ch.,
Hehlmann R.,
Hastka J.
Publication year - 2003
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2003.00118.x
Subject(s) - pathology , fluorescence in situ hybridization , lymphoma , population , cd38 , bone marrow , waldenstrom macroglobulinemia , interphase , medicine , mantle cell lymphoma , biology , immunology , chromosome , microbiology and biotechnology , genetics , environmental health , stem cell , gene , cd34
We report a case of Waldenström’ macroglobulinaemia, where the bone marrow analysis showed an almost complete infiltration by a heterogeneous population, consisting of 80% small lymphoplasmacytoid cells and 20% large atypical cells with multilobulated nuclei. Both cell populations were CD19+ and CD38+ and contained IgM. Fluorescence in situ hybridization analysis with a chromosome 8 painting probe on interphase nuclei revealed only two signals in each cell, including in those with multiple nuclei. Our findings suggest that the multilobulated nuclear structures are diploid and originate from a single nucleus. In contrast to the published multiple myeloma cases, our patient showed good response to chemotherapy. After successful chemotherapy, the morphology of the lymphoma changed into typical lymphoplasmacytoid lymphoma. The multilobulated population was no longer detectable. Five years after the initial diagnosis, the patient is still alive and in good health.