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Aplastic anaemia associated with a Philadelphia chromosome and monosomy 7 during immunosuppressive therapy
Author(s) -
Satoh Atsushi,
Miwa Hiroshi,
Daimaru Osami,
Imai Norikazu,
Hiramatsu Akihito,
Yamamoto Hidesuke,
Shikami Masato,
Imamura Akira,
Mihara Hidetsugu,
Nitta Masakazu
Publication year - 2003
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2003.00103.x
Subject(s) - monosomy , chromosome 7 (human) , medicine , bone marrow , dysplasia , aplastic anemia , chromosome , immunology , pathology , cancer research , karyotype , biology , genetics , gene
We describe a patient who presented with aplastic anaemia associated with the Philadelphia (Ph 1 ) chromosome during immunosuppressive therapy and who subsequently developed myelodysplastic syndrome (MDS) with monosomy 7. Initially the patient had hypocellular fatty marrow without leukaemic blasts or dysplastic features. Chromosome analysis showed 46, XY, t(9;22)(q34;q11) during immunosuppressive therapy, but no leukaemic transformation was detected. The patient showed gradual haematologic improvement and became transfusion independent. Thereafter, bone marrow dysplasia with monosomy 7 progressed following transfusion independence. These findings indicate that multiple cytogenetic evolutions occur in aplastic anaemia during immunosuppressive therapy, and that Ph 1 chromosome may play a role in bone marrow suppression rather than development of leukaemia.