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Post‐transfusion purpura (PTP) and disseminated intravascular coagulation (DIC)
Author(s) -
Welling KarenLise,
Taaning Ellen,
Lund Birgit V.,
Rosenkvist Jørgen,
Heslet Lars
Publication year - 2003
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2003.00092.x
Subject(s) - disseminated intravascular coagulation , medicine , platelet , purpura (gastropod) , fresh frozen plasma , antibody , coagulation , acute pancreatitis , plasmapheresis , gastroenterology , serology , immunology , ecology , biology
A 47‐yr‐old female with acute pancreatitis received four units of fresh frozen plasma because of subtle signs of disseminated intravascular coagulation (DIC). Seven days later, she developed severe thrombocytopenia. Serological studies demonstrated antibodies against HPA‐1a together with pan‐reactive antibodies against platelet glycoproteins (GPIIb‐IIIa, GPIb‐IX and GPIa‐IIa), which was consistent with the diagnosis of PTP. The patient was treated with platelet transfusions, corticosteroids and intravenous immunoglobulin (IVIG) without permanent beneficial effect. After treatment with plasma exchange the platelet count increased to normal values.