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Peripheral T‐cell lymphoma associated consecutively with hemophagocytic lymphohistiocytosis and hypereosinophilic syndrome
Author(s) -
Gutiérrez Antonio,
Solano Carlos,
Ferrández Antonio,
Marugán Isabel,
Terol María José,
Benet Isabel,
Tormo Mar,
Bea María Dolores,
Rodríguez José
Publication year - 2003
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2003.00051.x
Subject(s) - hypereosinophilia , hemophagocytic lymphohistiocytosis , medicine , lymphoma , hypereosinophilic syndrome , immunology , cd8 , tumor necrosis factor alpha , bone marrow , cytotoxic t cell , pathology , eosinophilia , biology , immune system , in vitro , biochemistry , disease
Both hemophagocytic lymphohistiocytosis and hypereosinophilic syndrome have been associated with hematologic neoplasms and are respectively related to an overproduction of the cytokines Thelper 1 (Th1) and Th2 by tumor cells or reactive cells. To our knowledge, this is the first time a case of a peripheral T‐cell lymphoma consecutively associated with both paraneoplastic conditions has been reported. Importantly, in this case when the lymphoma exclusively involved the bone marrow, severe paraneoplastic systemic damage, a CD8+ suppressor/cytotoxic phenotype and a hypereosinophilia not related to high levels of interleukin (IL)‐5 was found. Interestingly, progression of the lymphoma coincided with an increase in the serum levels of several Th2 cytokines and IL‐2, a decrease in tumor necrosis factor and granulocyte‐macrophage colony‐stimulating factor levels and the onset of a hypereosinophilic syndrome.