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Emergence of Philadelphia positive chronic myeloid leukaemia during treatment with hydroxyurea for Philadelphia negative essential thrombocythaemia
Author(s) -
Wahlin Anders,
Golovleva Irina
Publication year - 2003
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2003.00043.x
Subject(s) - chronic myeloid leukaemia , medicine , karyotype , bone marrow , myeloid , philadelphia chromosome , stem cell , transplantation , immunology , biology , chromosome , genetics , chromosomal translocation , gene
A 58‐yr‐old male patient with essential thrombocythaemia (ET) developed chronic myeloid leukaemia (CML) after continuous uneventful treatment with hydroxyurea for 18 yr. G‐banding analyses of bone marrow cells had repeatedly demonstrated normal male karyotype before this event, but t(9;22)(q34;q11) was demonstrated after the event. An unrelated allogeneic stem cell transplantation was performed. Blood and bone marrow morphology, and the karyotype were normalised and the patient is in good health 1 yr post‐transplant. There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.