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The prognostic significance of CA 125 in patients with non‐Hodgkin's lymphoma
Author(s) -
Zacharos Ioannis D.,
Efstathiou Stamatis P.,
Petreli Elisa,
Georgiou George,
Tsioulos Dimitrios I.,
Mastorantonakis Stylianos E.,
Christakopoulou Ioulia,
Roussou Paraskevi P.
Publication year - 2002
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2002.02771.x
Subject(s) - medicine , gastroenterology , immunoradiometric assay , international prognostic index , lymphoma , stage (stratigraphy) , b symptoms , hodgkin lymphoma , radioimmunoassay , rituximab , paleontology , biology
Objective : To assess the association of serum CA 125 in patients with non‐Hodgkin's lymphoma (NHL) with prognostic parameters of the disease, response to treatment, and survival. Patients and methods : Sixty‐eight patients [38 males, median age 56 (range 17–82) yr] with NHL were evaluated. CA 125 was measured by an enzyme immunoradiometric assay at diagnosis and at the end of first‐line treatment. Results : Median overall CA 125 was 49 (1–963) U mL −1 , whereas 49 patients had initially abnormal (>35 U mL) CA 125 levels. High CA 125 was found to correlate with failure of treatment ( P = 0.001) and relapse ( P = 0.01), and to be independently associated with bulky disease, effusions, LDH, and the International Prognostic Index (IPI) score ( P <0.01 for each of these four variables). An initially abnormal CA 125 value was associated with poorer 5‐yr survival [median survival of patients with CA 125>35 U mL −1 33 (18–72) months compared to 58 (20–77) months for those with CA 125 = 35 U mL −1 , P = 0.012]. Moreover, CA 125>35 U mL −1 (among stage III/IV and LDH>460 mU mL −1 ) emerged as an independent predictor of death within 5 yr from diagnosis (Relative Risk (RR) 3.1, 95% CI 1.5–12.8, P = 0.02). Conclusion : Measurement of serum CA 125 is useful for staging, monitoring, and estimating prognosis in patients with NHL.