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Chronic myeloid leukaemia in a man with myasthenia gravis treated by thymectomy
Author(s) -
Pavithran Keechilat,
Panakkel Charles,
Roy Dinesh,
Thomas Mathew
Publication year - 2002
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2002.02726.x
Subject(s) - myasthenia gravis , thymectomy , thymoma , medicine , chronic myeloid leukaemia , myeloid , philadelphia chromosome , mediastinal mass , immunology , gastroenterology , chromosomal translocation , pathology , biology , biochemistry , gene
Treatment‐related chronic myeloid leukaemia (CML) is a less commonly recognised entity. It differs from treatment‐related acute leukaemias in frequency, clinical course, and prognosis. Previously two cases of CML have been described following treatment of myasthenia gravis associated with thymoma treated by thymectomy. We report a 25‐yr‐old man with myasthenia gravis without thymoma who developed CML, 68 months after thymectomy. Cytogenetic study showed translocation (9,22)(q34;q11) with 10% showing double Ph chromosome. Reverse‐transcriptase polymerase chain reaction (RT‐PCR) of peripheral blood demonstrated the presence of p210 BCR/ABL with b3a2 transcripts. He was treated with hydroxyurea, and still remained in the chronic phase during the last 6 months of follow up. His myasthenic symptoms remained stable.