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Endogenous endophthalmitis following disseminated fungemia due to Fusarium solani in a patient with acute myeloid leukemia
Author(s) -
Tiribelli Mario,
Zaja Francesco,
Filì Carla,
Michelutti Teresa,
Prosdocimo Simonetta,
Candoni Anna,
Fanin Renato
Publication year - 2002
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2002.01674.x
Subject(s) - fungemia , medicine , fusarium solani , myeloid leukemia , endophthalmitis , leukemia , amphotericin b , vitrectomy , surgery , mycosis , dermatology , antifungal , visual acuity , microbiology and biotechnology , biology
We report the case of a young man with a resistant acute myeloid leukemia (AML) who developed a disseminated fungemia due to Fusarium solani involving the skin and lungs, during the neutropenic phase following a chemotherapy course. Despite continuous therapy with liposomal amphotericin B, he developed a bilateral endophthalmitis that rapidly evolved to complete blindness. The patient underwent two procedures of vitrectomy, with detection of F. solani in the vitreous fluid, and continued antifungal therapy, without any recovery of visual acuity. When he eventually died due to recurrence of leukemia and hemorrhagic shock, autopsy revealed a diffuse fusarial involvement of the central nervous sysytem.