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Is there any significance for intracellular crystals in plasma cells from patients with monoclonal gammopathies?
Author(s) -
Gardais J.,
Geneviève F.,
Foussard C.,
Delisle V.,
Zandecki M.
Publication year - 2001
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2001.t01-1-00485.x
Subject(s) - multiple myeloma , plasma cell , monoclonal , intracellular , pathology , paraproteinemias , immunoglobulin light chain , monoclonal antibody , antibody , medicine , biology , immunology , microbiology and biotechnology
Several plasma cells morphological changes have been described in monoclonal gammopathies, including intracytoplasmic crystals. We report one case of indolent κ‐chain multiple myeloma with renal insufficiency, featuring plasma cells with Auer‐rod‐like intracytoplasmic inclusions. The relationship between such aberrations and those found in multiple‐myeloma‐associated adult Fanconi syndrome is discussed. The significance of intracellular storage and crystallisation of immunoglobulin within plasma cells remains partially unknown.