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Successful treatment of an acquired haemorrhagic diathesis due to factor X deficiency with chemotherapy
Author(s) -
De Jager E.,
Bieger R.,
Castel A.,
Kluin PH. M.
Publication year - 2001
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2001.066005352.x
Subject(s) - medicine , plasma cell dyscrasia , chemotherapy , vincristine , prednisone , bleeding diathesis , dyscrasia , bone marrow , biopsy , hemorrhagic diathesis , amyloidosis , multiple myeloma , surgery , gastroenterology , plasma cell , cyclophosphamide , immunology , platelet , antibody , immunoglobulin light chain
A 70‐yr‐old woman presented with a severe haemorrhagic diathesis due to an acquired factor X deficiency. A plasma infusion study showed that exogenous factor X was eliminated very effectively from the patient's circulation. A bone marrow biopsy was consistent with plasma cell dyscrasia. Neither an abdominal fat biopsy nor the bone marrow biopsy confirmed an amyloidosis, although clinically no other diagnosis seemed possible. Treatment with intermittent chemotherapy, consisting of vincristine, cytoxan and prednisone, yielded definite clinical and laboratory improvement.