Premium
Successful treatment with low‐dose splenic irradiation for massive splenomegaly in an elderly patient with hairy‐cell leukemia
Author(s) -
Nishii Kazuhiro,
Katayama Naoyuki,
Maeda Hideaki,
Usui Eiji,
Takemitu Takashi,
Lorenzo V Felipe,
Nakase Kazunori,
Shiku Hiroshi
Publication year - 2001
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2001.00537.x
Subject(s) - splenectomy , medicine , hairy cell leukemia , refractory (planetary science) , spleen , leukemia , purine analogue , gastroenterology , purine , biochemistry , chemistry , physics , astrobiology , enzyme
The therapeutic approach to hairy‐cell leukemia (HCL) is in some instances still debated. Although management with α‐interferon and purine analogues is well established, there is an alternative role for therapeutic splenectomy in patients with massive splenomegaly who have failed to respond to systemic therapy. Most patients with HCL will not be suitable for treatment with splenectomy as their ages at diagnosis are high. Here, we report an elderly Japanese HCL patient whose refractory massive splenomegaly responded well to low‐dose splenic irradiation.