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A high serum‐soluble interleukin‐2 receptor level is associated with a poor outcome of aggressive non‐Hodgkin's lymphoma
Author(s) -
Niitsu Nozomi,
Iijima Kimiko,
Chizuka Aki
Publication year - 2001
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2001.00334.x
Subject(s) - medicine , lymphoma , univariate analysis , multivariate analysis , international prognostic index , stage (stratigraphy) , performance status , gastroenterology , interleukin 2 , oncology , receptor , overall survival , diffuse large b cell lymphoma , biology , paleontology
Soluble interleukin‐2 receptor (sIL‐2R) is produced by activated T and B cells, and the level of this receptor is elevated in patients with non‐Hodgkin's lymphoma (NHL). The present study demonstrated that the sIL‐2R level was high in the following groups of patients with aggressive NHL; those aged 60 yr, those with a poor PS, those in Ann Arbor stage III or IV, and those in the high–intermediate or high risk group according to the International Prognostic Index (IPI). Overall survival was significantly poorer when the sIL‐2R level was 2000 U/ml or more. In addition, the overall survival of patients in the low (L) and low–intermediate (L–I) risk groups with an sIL‐2R level of 3000 U/ml or more was significantly poorer, suggesting that the sIL‐2R level could be particularly useful for identifying patients with a poor prognosis among the L and L–I risk groups. Univariate analysis identified some significant prognostic factors, and multivariate analysis of these factors plus the five IPI prognostic factors showed that the sIL‐2R level was an independent prognostic indicator. In conclusion, the present findings established that the sIL‐2R level is a significant independent prognostic factor in patients with aggressive NHL.