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Organ specificity of c‐kit + lymphoid precursors in the liver, thymus, andbone marrow
Author(s) -
Shimizu Takao,
Bannai Makoto,
Kawamura Hiroki,
Yamamoto Satoshi,
Oya Hiroshi,
Maruyama Satoshi,
Minagawa Masahiro,
Kawamura Toshihiko,
Watanabe Hisami,
Hatakeyama Katsuyoshi,
Abo Toru
Publication year - 2000
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2000.90158.x
Subject(s) - bone marrow , spleen , myeloid , biology , immune system , haematopoiesis , lymphatic system , lymphopoiesis , stem cell , immunology , microbiology and biotechnology , pathology , medicine
c‐kit + Lin − cells are present in various immune organs, including the liver, thymus, and bone marrow, where lymphoid, myeloid, or erythroid cells are generated. To compare their properties as lymphoid precursors, c‐kit + Lin − cells purified from various organs of B6.Ly5.1 mice were injected into 6.5 Gy‐irradiated B6.Ly5.2 mice. Depending on the source of the c‐kit + cells, the degree of entrance and expansion of lymphoid cells differed in the liver and thymus of recipient mice. c‐kit + cells isolated from the bone marrow entered and expanded prominently in both the liver and thymus, whereas c‐kit + cells from the thymus did not do so at all. On the other hand, c‐kit + cells isolated from the liver and spleen showed an intermediate pattern, namely, they took a long time to enter and expand in the liver and thymus of recipient mice. All of these c‐kit + cells had the potential to give rise to lymphoid cells, which were specific to the liver and thymus, respectively. We previously showed that progenitor cells for extrathymic T cells in the liver and those for conventional T cells in the thymus are not always supplied by the bone marrow, as shown by experiments using parabiosis. Taken together with those previous data, the present results suggest that c‐kit + Lin − cells isolated from various immune organs have organ specific properties.