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Arterial thrombosis associated with anticardiolipin and anti‐β2‐glycoprotein‐Iantibodies in patients with non‐Hodgkin's lymphoma: a report of two cases
Author(s) -
Genvresse I.,
Buttgereit F.,
SpäthSchwalbe E.,
Ziemer S.,
Eucker J.,
Possinger K.
Publication year - 2000
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2000.065005344.x
Subject(s) - medicine , thrombosis , lupus anticoagulant , antiphospholipid syndrome , lymphoma , antibody , immunology , gastroenterology , pathology
Autoimmune phenomena in lymphoid malignancies are often observed. However, clinical manifestations such as a secondary antiphospholipid syndrome in the presence of antiphospholipid antibodies are rarely reported. Furthermore, in the few cases of lymphomas so far reported with thrombosis associated with elevated antiphospholipid antibodies, the anti‐β2‐glycoprotein‐I antibodies have not been studied. We report on two cases of arterial thrombosis occuring in patients with B‐cell lymphoma who presented with positive anti‐cardiolipin and anti‐β2‐glycoprotein‐I antibodies. Our observation suggests that patients with non‐Hodgkin's lymphoma and both anti‐cardiolipin and anti‐β2‐glycoprotein‐I antibodies may be, similar to lupus patients, at considerable risk towards thrombosis, especially towards arterial thrombosis.