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Primary cutaneous lymphoblastic lymphoma presenting in an 8‐week old infant
Author(s) -
Trupiano Jacqueline K.,
Bringelsen Karen,
Hsi Eric D.
Publication year - 2002
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1034/j.1600-0560.2001.290208.x
Subject(s) - immunophenotyping , cd43 , lymphoblastic lymphoma , lymphoma , cd20 , pathology , cd99 , histopathology , cd19 , medicine , cd34 , cd15 , b cell , cd5 , antibody , immunohistochemistry , flow cytometry , immunology , biology , t cell , stem cell , vimentin , immune system , genetics
Background: We report a case of primary cutaneous lymphoblastic lymphoma (LBL) presenting in an 8‐week‐old infant. Methods: Histopathology and flow cytometric analysis confirmed the diagnosis of a lymphoblastic lymphoma. The cells expressed CD19, CD20, CD34 and surface immunoglobulin (sIg). Results: The cells were negative for TdT and CD99. This unusual immunophenotype has been described as “transitional pre‐B‐cell”, in that the cells express both immature markers (CD34) and mature markers (sIg). Conclusions: To our knowledge, only five other cases of sIg positive precursor B‐cell LBL have been reported in the literature. This may represent the youngest reported case of primary cutaneous LBL, occurring at 8 weeks of age.