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Dermatofibroma‐like granular cell tumor
Author(s) -
Cheng Stephanie D.,
Usmani Arif S.,
DeYoung Barry R.,
Ly Micki,
Pellegrini Arthur E.
Publication year - 2001
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1034/j.1600-0560.2001.280106.x
Subject(s) - dermatofibroma , factor xiiia , enolase , pathology , granular cell tumor , immunohistochemistry , granular cell , h&e stain , fibroma , medicine , biology , endocrinology , central nervous system
Background: There have been several reports in the literature of dermatofibromas with granular cells. Here we report a granular cell tumor with the architecture of a dermatofibroma. This is the first report of this histological variant of granular cell tumor. The lesion was a 2.5‐cm oval, hyperpigmented plaque present for “years” on the back of a 60‐year‐old African‐American woman. Methods: The specimen was processed using formalin fixation and paraffin embedding. Tissue sections were stained with hematoxylin and eosin. Immunohistochemical studies were performed with antibodies directed against S‐100 protein, neuron‐specific enolase, and factor XIIIa. Results: Histopathologic examination revealed granular cells, some of which were spindle shaped, distributed singly and in small groups between collagen bundles resembling a dermatofibroma. Immunohistochemical studies showed the tumor cells to be positive for S‐100 and neuron‐specific enolase and negative for factor XIIIa. Conclusion: The immunohistochemical findings support the diagnosis of a granular cell tumor with a dermatofibroma‐like pattern.