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Granulomatous slack skin: an ultrastructural study
Author(s) -
Tsuruta Daisuke,
Kono Takeshi,
Kutsuna Haruo,
Yashiro Noriko,
Ishii Masamitsu
Publication year - 2001
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1034/j.1600-0560.2001.280105.x
Subject(s) - histiocyte , giant cell , pathology , ultrastructure , granuloma , multinucleate , biology , medicine
Background: Granulomatous slack skin is a rare lymphoproliferative disorder characterized clinically by gradual development of pendulous folds of lax erythematous skin in flexural areas, and histologically by non‐necrotizing granuloma, with numerous multinucleated giant cells, mononuclear histiocytes, and atypical lymphocytes associated with loss of elastic fibers. Although there are many reports describing the histological and immunophenotypic features of this disease, only a few have described the ultrastructural features. Methods: Here we report a case of granulomatous slack skin and describe the ultrastructural findings. Results and conclusion: We could detect some previously not noted abnormal findings in multinucleated giant cells, histiocytes, and atypical lymphocytes.