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Subcutaneous malignant epithelioid schwannoma with cartilaginous differentiation
Author(s) -
Yamamoto Tetsuji,
Minami Rieko,
Ohbayashi Chiho
Publication year - 2001
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1034/j.1600-0560.2001.028009486.x
Subject(s) - vimentin , pathology , immunohistochemistry , schwannoma , epithelioid cell , glial fibrillary acidic protein , cytokeratin , keratin , enolase , biology , medicine
Background: Malignant epithelioid schwannoma is a rare tumor. The aim of this study is to describe a case of subcutaneous malignant epithelioid schwannoma with cartilaginous differentiation. Methods: Histological, immunohistochemical, and ultrastructural examinations were performed on a tumor that arose on the back of a 37‐year‐old woman. Results: Histologically, the tumor predominantly consisted of small, round or polygonal cells arranged in cords or nests. Immunohistochemical study revealed that the tumors cells were positive for vimentin, S‐100 protein, glial fibrillary acidic protein and neuron specific enolase. The cells were negative for HMB‐45, keratin, epithelial membrane antigen, and CAM5.2. Electron microscopic study showed closely associated cells with undifferentiated features. The cells were devoid of external laminae and cellular junctions. Conclusion: Malignant epithelioid schwannoma should be pathologically differentiated from other epithelioid tumors with cartilaginous elements.