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Tumor‐infiltrating T cells in primary cutaneous B‐cell lympho‐proliferative disorders
Author(s) -
Kamarashev Jivko,
Schaerer Leo,
Burg Günter,
Hess Schmid Monika,
Müller Beatrix,
Kempf Werner
Publication year - 2001
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1034/j.1600-0560.2001.028009448.x
Subject(s) - pathology , medicine , primary (astronomy) , physics , astronomy
Background: Tumor‐infiltrating lymphocytes (TILs) are considered to play an important role in the antitumoral immune response. The presence and percentage of CD8‐positive tumor‐infiltrating T cells have been shown to correlate with differentiation and prognosis in various neoplasms. The aim of this study was to determine the number of CD8‐positive T cells in various primary cutaneous B‐cell lymphoproliferative disorders and to evaluate its correlation with the histological type of tumor. Methods: Fifty‐three lesions were examined by immunohistochemistry with antibodies targeting CD3, CD4, CD8 and TIA‐1. Thirty‐two lesions had been diagnosed as primary cutaneous B‐cell lymphomas (CBCL) and 21 as B‐cell pseudolymphomas (B‐PSL). CBCLs included 15 follicular lymphomas (FL), 6 marginal zone lymphomas (MZL), and 11 diffuse large B‐cell lymphomas (LCL). The number of CD8‐positive cytotoxic T cells was determined by computer‐assisted morphometrical microscopy. Results: No significant difference could be detected in the density of CD8‐positive T cells in B‐PSL (101/10 5 μm 2 ), FL (110/10 5 μm 2 ), and MZL (122/10 5 μm 2 ). In contrast, the number of CD8‐positive cells (55/10 5 μm 2 ) in LCL was significantly lower (p<0.01) compared to B‐PSL, FL and MZL. Conclusions: In summary the number of CD8‐positive T cells in B‐cell lymphoproliferative disorders differs in regard to tumor type and differentiation with lowest numbers in diffuse large B‐cell lymphomas. However, due to an overlap of the number of TILs, this parameter cannot be employed as a diagnostic parameter for individual cases.