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The histologic value of adnexal (eccrine gland and follicle) infiltration in mycosis fungoides
Author(s) -
Rongioletti F.,
Smoller B.
Publication year - 2000
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1034/j.1600-0560.2000.027008406.x
Subject(s) - mycosis fungoides , pathology , medicine , infiltration (hvac) , biopsy , follicular phase , hair follicle , follicle , follicular hyperplasia , hyperplasia , lymphoma , physics , thermodynamics
Background: To verify the incidence and the possible diagnostic use of detecting adnexotropism in mycosis fungoides (MF). Methods: We reviewed the frequency and the intensity of the eccrine and follicular infiltration in 104 biopsy specimens from indisputable cases of MF and in a control group of 20 biopsy specimens of spongiotic dermatitis. Syringohyperplasia and follicular mucinosis were also evaluated. Results: A prominent eccrine infiltration was noted in 32 of 104 specimens (30%). Marked acrosyringial and ductal eccrine hyperplasia was present in 5 specimens (5%). In 13 of the 32 specimens with prominent eccrine infiltration (40%), epidermotropism was slight or less evident than syringotropism. Follicular structures were visible in 59 specimens and significantly infiltrated in 57%. Follicular mucinosis was found in 5 (8.4%). In the control group of spongiotic dermatitis, a significant eccrine and follicular infiltration was found only in 1 case (5%). Conclusions: Adnexal (eccrine gland and follicle) infiltration may be a useful diagnostic tool in MF, particularly in those in which epidermotropism is slight.