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Is there a special relationship between CD30‐positive lymphoproliferative disorders and epidermal proliferation?
Author(s) -
Cespedes Yvana P.,
Rockley Paul F.,
Flores Frank,
Ruiz Phillip,
Kaiser Mark R.,
Elgart George W.
Publication year - 2000
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1034/j.1600-0560.2000.027006271.x
Subject(s) - cd30 , lymphomatoid papulosis , lymphoma , pathology , immunohistochemistry , lymphoproliferative disorders , medicine , lymphomatoid granulomatosis , immunology
The relationship between CD30+ lymphoma and epithelial proliferations is not well defined. CD30+ lymphoma and lymphomatoid papulos (LyP) share immunohistochemical epitopes and some other features. A single case of LyP associated with multiple keratoacanthomas (KAs) was recently reported. We report two cases of atypical lymphocytic proliferation with features of CD30+ lymphoma and LyP intimately associated to KA and squamous cell carcinoma (SCC), KA type. This similar combination of an epidermal tumor and apparent involvement with atypical lymphocytic infiltrates raises the possibility of an association between the two entities. We speculate that the association may be more than expected to occur by chance and suggest several mechanisms by which the association may evolve.