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Epithelioid blue nevus: a rare variant of blue nevus not always associated with the Carney complex
Author(s) -
Moreno Carmen,
Requena Luis,
Kutzner Heinz,
Cruz Alberto,
Jaqueti Gerardo,
Yus Evaristo Sánchez
Publication year - 2000
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1034/j.1600-0560.2000.027005218.x
Subject(s) - blue nevus , carney complex , nevus , medicine , dermatology , pathology , epithelioid cell , nevus of ota , melanoma , biology , immunohistochemistry , cancer research , biochemistry , gene
Epithelioid blue nevus is a rare variant of blue nevus that has been recently described in patients with Carney complex. Some of the patients with Carney complex have multiple epithelioid blue nevi and a familial history of similar lesions is often recorded. Epithelioid blue nevus consists of an intradermal melanocytic nevus composed of polygonal epithelioid cells laden with melanin. Neoplastic cells show no maturation at the base of the lesion and, in contrast with the usual stromal changes in blue nevi, epithelioid blue nevus exhibits no fibrosis of the dermis. We have studied three cases of epithelioid blue nevus in three patients with no evidence of Carney complex. The lesions were solitary and there was no family history of similar lesions. Therefore, epithelioid blue nevus is a distinctive variant of blue nevus that may also appear as a sporadic lesion and is not always associated with Carney complex.