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Apoptosis in the areas of squamous differentiation of irritated seborrheic keratosis
Author(s) -
Pesce Carlo,
Scalora Stefano
Publication year - 2000
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1034/j.1600-0560.2000.027003121.x
Subject(s) - seborrheic keratosis , hyperkeratosis , apoptosis , keratosis , biology , cancer research , pathology , keratin , acanthosis , involution (esoterism) , cell , keratinocyte , dermatology , medicine , cell culture , consciousness , biochemistry , genetics , neuroscience
Seborrheic keratosis (SK) consists of a localized proliferation of basaloid keratinocytes, often accompanied by hyperkeratosis and hyperpigmentation. In irritated SK, these features are associated with areas of squamous differentation with larger keratinocytes and squamous cell eddies. This work is concerned with the evaluation of apoptosis, as demonstrated by the TUNEL method, in the different varieties of SK. Apoptosis was highly expressed in the areas of squamous differentiation of irritated SK, but only mildly increased in the other varieties of SK. These data support the hypothesis that apoptosis has a role in the squamous differentiation of irritated SK. In consideration also of previous data showing that irritated SK is associated with downregulation of EGF‐R expression and 125 I‐EGF binding, we postulate that the morphologic features of irritated SK could correspond to an involution phase of the disease, characterized by altered cell balance with inadequate cell renewal and increased cell loss.