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Generalized pruritic eruption with suprabasal acantholysis preceeding the development of bullous pemphigoid
Author(s) -
Barnadas María A.,
Pujol Ramón M.,
Curell Román,
MatíasGuiu Xavier,
Alomar Agustín
Publication year - 2000
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1034/j.1600-0560.2000.027002096.x
Subject(s) - acantholysis , spongiosis , bullous pemphigoid , pathology , eosinophilic , medicine , pemphigoid , pemphigus , dermatology , dermatopathology , antibody , autoantibody , immunology
We report a patient who presented with a papular pruritic eruption of a 3‐month duration that histologically showed suprabasal acantholysis accompanied of an eosinophilic inflammatory infiltrate that was consistent with the diagnosis of Grover's disease. Later, erythematous plaques and vesicles appeared which showed a histopathological pattern of eosinophilic spongiosis. The direct immunofluorescence (DIF) study showed lineal IgG and C′3 at the dermal epidermal junction which was consistent with the diagnosis of bullous pemphigoid. No anti‐intercellular deposits of immunoglobulin G (IgG) or C′3 were observed. We consider that suprabasal acantholysis may represent the early phase of bullous pemphigoid.