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Sensitizing capacity and cross‐reaction pattern of the isomers of diglycidyl ether of bisphenol F in the guinea pig
Author(s) -
Pontén A.,
Zimerson E.,
Sörensen Ö.,
Bruze M.
Publication year - 2002
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1034/j.1600-0536.2002.470507.x
Subject(s) - diglycidyl ether , epoxy , ether , bisphenol a , chemistry , polymer chemistry , sensitization , organic chemistry , medicine , immunology
In this study, the sensitizing capacities of the 3 main low‐molecular‐weight isomers of epoxy resins based on diglycidyl ether of biphenol F (DGEBF) were investigated in a guinea pig maximization test (GPMT). The isomers are p,p′‐DGEBF, o,p′‐DGEBF, and o,o′‐DGEBF. The sensitization capacities were compared to diglycidyl ether of bisphenol A (DGEBA), which is the main constituent in the most common epoxy resin. The cross‐reaction pattern between all 4 compounds was also investigated. It was found that all 3 DGEBF isomers were potent sensitizers. It was also found that p,p′‐DGEBF, o,p′‐DGEBF, and DGEBA cross‐reacted with one another, and that animals induced with o,o′‐DGEBF reacted significantly only to o,p′‐DGEBF, but not to the other 2 DGEBF isomers or DGEBA.