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Contact allergy to the monomers in p‐ tert ‐butylphenol‐formaldehyde resin
Author(s) -
Zimerson Erik,
Bruze Magnus
Publication year - 2002
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1034/j.1600-0536.2002.470304.x
Subject(s) - contact allergy , formaldehyde , allergy , monomer , contact dermatitis , allergic contact dermatitis , dermatology , occupational exposure , medicine , polymer chemistry , chemistry , organic chemistry , immunology , medical emergency , polymer
In many adhesive formulations p‐ tert ‐butylphenol‐formaldehyde resin (PTBP‐F‐R) is used as a binder. Contact allergy to this resin is not rare. In patients hypersensitive to PTBP‐F‐R, and butylphenol derivatives therein, it is for diagnostic and preventive reasons necessary to know the nature of the primary sensitizing substances, as well as the cross‐reaction patterns for these. The aim of this study was to investigate contact allergy to monomers in PTBP‐F‐R and potential cross‐reacting substances. 12 patients hypersensitive to PTBP‐F‐R were patch tested with 2 monomers, the raw materials formaldehyde and p‐ tert ‐butylphenol, and 3 closely related substances. High pressure liquid chromatography (HPLC) was used to investigate the purity of the test substances. It was shown that the monomers 2‐methylol p‐ tert ‐butylphenol and 2,6‐dimethylol p‐ tert ‐butylphenol could elicit allergic reactions in humans hypersensitive to PTBP‐F‐R. No simultaneous reactions or cross‐reactions were shown to formaldehyde, p‐ tert ‐butylphenol, p‐ tert ‐butylcatechol, 2(3)‐ tert ‐butyl‐4‐hydroxyanisole (BHA) or 3,5‐di‐ tert ‐butyl‐4‐hydroxytoluene (BHT). It was also shown that low amounts of contaminants in the test substances, if not taken into account, could influence the conclusions drawn from the test results obtained.