Premium
Monitoring levels of preservative sensitivity in Europe
Author(s) -
Wilkinson J. D.,
Shaw S.,
Andersen K. E.,
Brandao F. M.,
Bruynzeel D. P.,
Bruze M.,
Camarasa J. M. G.,
Diepgen T. L.,
Ducombs G.,
Frosch P. J.,
Goossens A.,
Lachappelle J. M.,
Lahti A.,
Menné T.,
Seidenari S.,
Tosti A.,
Wahlberg J. E.
Publication year - 2002
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1034/j.1600-0536.2002.460404.x
Subject(s) - preservative , medicine , formaldehyde , sensitivity (control systems) , environmental health , chemistry , food science , organic chemistry , electronic engineering , engineering
A 10‐year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5‐chloro‐2‐methyl‐4‐isothiazolin‐3‐one + 2‐methyl‐4‐isothiazolin‐3‐one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re‐evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave‐on products.