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Relationship between 2,4‐dinitrochlorobenzene elicitation responses and individual irritant threshold
Author(s) -
Smith H. R.,
Kelly D. A.,
Young A. R.,
Basketter D. B.,
McFadden J. P.
Publication year - 2002
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1034/j.1600-0536.2002.460207.x
Subject(s) - allergic contact dermatitis , sensitization , irritant contact dermatitis , contact allergy , dermatology , allergy , contact dermatitis , reactivity (psychology) , hapten , patch testing , immunology , chemistry , medicine , antibody , pathology , alternative medicine
Contact dermatitis shows significant interindividual variation. We studied the relationship between an individual's irritant threshold and the elicitation of experimentally induced allergic sensitization. The results suggest that there is an association between reactivity to an irritant and the likelihood of positive elicitation reactions to lower hapten concentrations. This novel finding would be compatible with the proposal that contact allergy is best explained using a danger model with cutaneous irritancy determining sensitization. However, the enhanced allergic reactivity of individuals with a lower irritant threshold was not apparent on visual inspection, suggesting that the determinants of skin reactivity to haptens are multifactorial.