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Fragrance contact dermatitis: a worldwide multicenter investigation (Part II)
Author(s) -
Larsen Walter,
Nakayama Hideo,
Fischer Torkil,
Elsner Peter,
Frosch Peter,
Burrows Desmond,
Jordan William,
Shaw Stephanie,
Wilkinson John,
Marks James,
Sugawara M.,
Nethercott Marc,
Nethercott James
Publication year - 2001
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1034/j.1600-0536.2001.044006344.x
Subject(s) - citronellol , geranium , contact dermatitis , allergic contact dermatitis , patch testing , dermatology , medicine , chemistry , essential oil , allergy , food science , geraniol , biology , horticulture , immunology , cultivar
The purpose of this study was to determine the frequency of responses to selected fragrance materials in patients who were fragrance sensitive. 178 patients were evaluated in 8 centers worldwide with a fragrance mix (FM) and 20 other fragrance materials. Reaction to the fragrance mixture (FM) occurred in 78.7% of the subjects. Substances reacting at a rate of 2% or higher included jasmine absolute, geranium oil bourbon, l‐citronellol, spearmint oil, 1,3,4,6,7,8‐hexahydro‐4,6,6,7,8,8‐hexamethylcyclopenta‐γ‐2‐benzopyran, omega‐6‐hexadecenlactone, dimethyltetrahydrobenzaldehyde (isomer mixture), and α‐amylcinnamaldehyde. These chemicals should be furthur evaluated to corroborate their allergenicity. We are constantly looking for new fragrance allergens to extend the diagnostic capability of the fragrance mix (FM).