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Effect of different moisturizers on SLS‐irritated human skin
Author(s) -
Held Elisabeth,
Lund Henrik,
Agner Tove
Publication year - 2001
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1034/j.1600-0536.2001.044004229.x
Subject(s) - moisturizer , transepidermal water loss , medicine , volunteer , forearm , irritation , dermatology , contact dermatitis , surgery , stratum corneum , allergy , pathology , chemistry , food science , agronomy , immunology , biology
Moisturizers are widely used to treat irritant contact dermatitis (ICD). Their use is, however, not well‐documented and standardized models for testing skin care products are needed to acquire documentation of their efficacy. The present study was undertaken to evaluate the effect of 6 commonly‐used moisturizers on the recovery of irritated human skin. No commercial interests were involved in the study. 36 healthy volunteers had patch tests with SLS 0.5% applied on their forearms/upper arms for 24 h. After irritation of the skin, all volunteers had a moisturizer applied on one forearm/upper arm, respectively, 3 × daily for the following 5 days. The other forearm/upper arm served as an untreated control. Each moisturizer was tested on 12 volunteers and each volunteer tested 2 moisturizers at the same time. Evaluation was done on days 1, 3 and 8 by transepidermal water loss, electrical capacitance, laser Doppler flowmetry, DermaSpectrometry and clinical scoring. All 6 moisturizers were found to accelerate regeneration of the skin barrier function when compared to irritated non‐treated skin. The most lipid‐rich moisturizers improved barrier restoration more rapidly than the less lipid‐rich moisturizers. We suggest this experimental model for further moisturizer efficacy testing.