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Sensitizing capacity of 5,5′‐di‐tert‐butyl‐2,2′‐dihydroxy‐(hydroxymethyl)‐dibenzyl ethers in the guinea pig
Author(s) -
Zimerson Erik,
Bruze Magnus
Publication year - 2000
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1034/j.1600-0536.2000.043002072.x
Subject(s) - chemistry , hydroxymethyl , formaldehyde , ether , guinea pig , phenol , medicinal chemistry , stereochemistry , polymer chemistry , organic chemistry , medicine , endocrinology
In patients hypersensitive to p‐tert‐butylphenol‐formaldehyde resin (PTBP‐F‐R), it is for diagnostic, therapeutic and preventive reasons necessary to know the identity of the primary sensitizing substances, their sensitizing capacities as well as their cross‐reaction patterns. We have recently shown that the 2 dimers in PTBP‐F‐R, 5,5′‐di‐tert‐butyl‐2,2′‐dihydroxy‐3‐hydroxymethyl‐dibenzyl ether (X) and 5,5′‐di‐tert‐butyl‐2,2′‐dihydroxy‐3,3′‐dihydroxymethyl‐dibenzyl ether (IX) are contact sensitizers in man. The aim of this study was to investigate the sensitizing capacities of these dimers in PTBP‐F‐R and potential cross‐reacting substances in the guinea pig with the guinea pig maximization test. IX, X, 2,6‐dimethylol‐p‐tert‐butylphenol (2,6‐MPTBP), 2‐methylol‐p‐tert‐butylphenol (2‐MPTBP), p‐tert‐butylcatechol (PTBC), 5,5′‐di‐tert‐butyl‐2,2′‐dihydroxy‐dibenzyl ether (XI) were used as possible cross reacting substances. IX and X were shown to be sensitizers. When compared to the sensitizers in phenol‐formaldehyde resin, IX is a strong sensitizer ( p =0.00052) and X a moderate sensitizer ( p =0.0053). Animals sensitized to IX showed cross‐reactions to X ( p =0.010), 2,6‐MPTBP ( p =0.0011) and PTBC ( p =0.0498). Animals sensitized to X showed no cross‐reactions to the substances that were tested. The results indicate that IX is a main allergen in PTBP‐F‐R, with possibly also X.