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Severe dermographism after topical therapy with diphenylcyclopropenone for alopecia universalis
Author(s) -
Skrebova Natalja,
Nameda Yumiko,
Takiwaki Hirotsugu,
Arase Seiji
Publication year - 2000
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1034/j.1600-0536.2000.042004212.x
Subject(s) - medicine , dermatology , scalp , contact dermatitis , alopecia universalis , surgery , allergy , immunology
We describe here a 19‐year‐old Japanese man with an 11‐year history of alopecia universalis, who, after the 1st application of a 0.003% diphenylcyclopropenone (DPCP) solution to the whole scalp, developed acute contact dermatitis at the test site, together with widespread severe dermographism. Every 3 weeks, persistence of the severe urticarial reaction and efficacy of treatment were monitored by constant pressure stimuli in a series of pressure tests, and subsequently evaluated by laser Doppler flowmetry (LDF). Although, on pressure tests, the urticarial response was found to significantly improve after starting treatment, erythematous responses continued to appear for nearly 3 months. The persistent course of these side‐effects in our patient strongly suggests that precautions must currently be taken in the therapeutic use of potent sensitizers such as DPCP.