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Activation and cross‐reactivity pattern of a new allergen in adhesive plaster
Author(s) -
Bergendorff O.,
Hansson C.
Publication year - 2000
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1034/j.1600-0536.2000.042001011.x
Subject(s) - salicylaldehyde , ethylenediamine , adhesive , chemistry , patch test , copper , reactivity (psychology) , hydrolysis , diamine , high performance liquid chromatography , nuclear chemistry , polymer chemistry , organic chemistry , schiff base , medicine , allergy , alternative medicine , layer (electronics) , pathology , immunology
N,N′‐disalicylidene‐1,2‐diaminopropane is a copper inhibitor present in some adhesive plasters, rubber products and gasoline. Upon contact with water it is hydrolyzed to salicylaldehyde and 1,2‐diaminopropane. All patients in this study showed positive patch‐test reactions to N,N′‐disalicylidene‐1,2‐diaminopropane, and also to 1,2‐diaminopropane and ethylenediamine. None reacted to salicylaldehyde. Patch testing with different N,N′‐disalicylidene‐derivatives showed localization of the amino groups in positions 1 and 2 to be a prerequisite of cross‐reactivity to 1,2‐diaminopropane and ethylenediamine. An extraction procedure and a high‐performance liquid chromatography (HPLC) method for the analysis of adhesive plasters is described. Studies of the hydrolysis of the copper inhibitor at physiological pH showed rapid formation of 1,2‐diaminopropane under biomimetic conditions.