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Systemic medications: clinical significance in periodontics
Author(s) -
Ciancio Sebastian G.
Publication year - 2002
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.29.s2.3.x
Subject(s) - medicine , periodontology , antibiotics , periodontitis , porphyromonas gingivalis , matrix metalloproteinase , pharmacology , chronic periodontitis , dentistry , biology , microbiology and biotechnology
Systemic medications are of value as adjuncts to periodontal therapy. These medications can be divided into two major categories: antibiotics and agents for host modulation. Antibiotics have been shown to be valuable adjuncts in specialized types of periodontal disease, such as localized and generalized aggressive periodontitis, and of possible value in severe chronic periodontitis. Antibiotics have been studied individually, in combination and in sequential therapy. Host modulators include Periostat, non‐steroidal anti‐inflammatory agents, alendronate (Fosamax), hormone replacement therapy and anti‐arthritic medications. These agents produce their beneficial effects by a variety of mechanisms of action, including inhibition of matrix metalloproteinases, inhibition of prostaglandin production, stimulation of osteoblasts, inhibition of osteoclasts, and other anti‐inflammatory mechanisms of action.