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Efficacy of an amine fluoride–triclosan mouthrinse as compared to the individual active ingredients
Author(s) -
Arweiler Nicole B.,
Auschill Thorsten M.,
Baguley Natascha,
Netuschil Lutz,
Sculean Anton
Publication year - 2003
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.2003.10250.x
Subject(s) - triclosan , chlorhexidine , dentistry , fluoride , medicine , biofilm , toothbrush , oral hygiene , placebo , adverse effect , dental plaque , chemistry , materials science , bacteria , biology , inorganic chemistry , brush , alternative medicine , pathology , composite material , genetics
Background: The purpose of the clinical study was to examine the antibacterial and plaque‐reducing properties of mouthrinses containing triclosan (TRI), amine fluoride (AmF), and the combination of both (AFT) on 4‐day plaque regrowth. A placebo solution (PLA) and a 0.2% chlorhexidine solution (CHX) served as negative and positive controls, respectively. Materials & Methods: After a professional tooth cleaning (day 0), 15 volunteers refrained from all mechanical oral hygiene measures for the next 96 h and rinsed instead twice daily for 1 min with 10 ml of one of the five randomly assigned solutions. Plaque index (PlI), which was assessed after 24 and 96 h (PlI1, PlI2), and plaque area of the front teeth (PA), which was planimetrically recorded from disclosed teeth after 96 h, served as clinical parameters. After 24 and 96 h a plaque sample was taken and analyzed microbiologically to evaluate biofilm vitality (VF1, VF2). The subsequent test cycles were conducted after a washout period of 10 days each. Results: No severe adverse events or allergy were seen during the study. CHX influenced all parameters at all time points in comparison to PLA. AFT and AmF showed very similar values (in all parameters), but AmF did not reach the level of significance regarding VF1, nor did AFT with VF2 and PlI1. The TRI solution only reduced PlI2 and PA significantly, but had no influence on biofilm vitality when compared to PLA. Conclusion: A synergism between AmF and TRI was not observed. The results suggest that the plaque‐reducing and antibacterial effects of the AFT solution are mainly based on the effects of the amine fluoride moiety.