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Réparation parodontale chez le chien: rhBMP‐2 augmente significativement la formation osseuse sous les matériaux pour régénération tissulaire guidée.
Author(s) -
Wikesjö Ulf M. E.,
Xiropaidis Andreas V.,
Thomson Robert C.,
Cook Alonzo D.,
Selvig Knut A.,
Hardwick W. Ross
Publication year - 2003
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.2003.00363.x
Subject(s) - dental alveolus , dentistry , medicine , regeneration (biology) , premolar , ankylosis , periodontal surgery , bone formation , bone morphogenetic protein 2 , wound healing , surgery , chemistry , molar , biochemistry , in vitro , biology , microbiology and biotechnology
Background: Recombinant human bone morphogenetic protein‐2 (rhBMP‐2) has been shown to support the regeneration of alveolar bone and periodontal attachment in surgically created periodontal defects and in defects with a history of dental plaque and calculus exposure. Periodontal regeneration has also been shown following guided tissue regeneration using space‐providing expanded polytetrafluoroethylene (ePTFE) devices. The objective of this study was to evaluate the influence of rhBMP‐2 on regeneration of alveolar bone and periodontal attachment used in conjunction with a space‐providing ePTFE device. Methods: Routine, critical‐size, 5–6 mm, supra‐alveolar, periodontal defects were created around the third and fourth mandibular premolar teeth in four young adult Hound Labrador mongrel dogs. rhBMP‐2 (0.2 mg/ml) in an absorbable collagen sponge (rhBMP‐2/ACS) or buffer/ACS (control) implants were randomly assigned to be placed around the premolar teeth in the left and right jaw quadrants in subsequent animals. Space‐providing ePTFE devices with 300‐ μ m laser‐drilled pores, 0.8 mm apart, were used to cover the rhBMP‐2 and control implants. The gingival flaps were advanced for primary wound closure. The animals were euthanized at 8 weeks postsurgery for histologic and histometric analyses. Results: Bone regeneration and ankylosis were significantly increased in jaw quadrants receiving rhBMP‐2/ACS compared to control (bone height 4.8±0.3 versus 2.0±0.2 mm, p =0.001; bone area 10.9±1.3 versus 1.4±0.1 mm 2 ; p =0.009, and ankylosis 2.2±0.2 versus 0.04±0.7 mm; p =0.01). No differences between groups were found for cementum regeneration and root resorption. Conclusions: rhBMP‐2 significantly enhances regeneration of alveolar bone in conjunction with a space‐providing, macroporous ePTFE device for GTR.