Premium
Cytokine levels in crevicular fluid are less responsive to orthodontic force in adults than in juveniles
Author(s) -
Ren Yijin,
Maltha Jaap C.,
Van′t Hof Martin A.,
Von den Hoff Johannes W.,
KuijpersJagtman Anne Marie,
Zhang Ding
Publication year - 2002
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.2002.290813.x
Subject(s) - medicine , prostaglandin e2 , radioimmunoassay , mediator , dentistry , juvenile , young adult , physiology , biology , genetics
Objectives: Bone remodelling during orthodontic tooth movement is related to the expression of mediators in gingival crevicular fluid (GCF). No information is available concerning the effect of age on the levels of these mediators in GCF. The purpose of this study was to quantify three mediators (prostaglandin E 2 , interleukin‐6 and granulocyte‐Macrophage Colony‐Stimulating Factor) in GCF during orthodontic tooth movement in juveniles and adults . Material and methods: A total of 43 juvenile patients (mean age 11 ± 0.7 year), and 41 adult patients (mean age 24 ± 1.6 year) took part in the study. One of the lateral incisors of each patient was tipped labially, the other served as control. GCF samples were taken before force activation (t 0 ) and 24 h later (t 24 ). Mediator levels were determined by radioimmunoassay (RIA). Results: PGE 2 concentrations were significantly elevated at t 24 in juveniles and adults, while concentrations of IL‐6 and GM‐CSF were significantly elevated only in juveniles. Total amounts of all three mediators in GCF significantly increased at t 24 in both groups. Conclusions: In early tooth movement, mediator levels in juveniles are more responsive than levels in adults, which agrees with the finding that the initial tooth movement in juveniles is faster than in adults and starts without delay.