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Application locale d'acides gras poly‐insaturés n −3 ou n −6 dans le traitement de la gingivite expérimentale humaine
Author(s) -
Eberhard Jörg,
Heilmann Frederik,
Açil Yahya,
Albers Hans Karl,
Jepsen Søren
Publication year - 2002
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.2002.290413.x
Subject(s) - polyunsaturated fatty acid , gingivitis , arachidonic acid , leukotriene b4 , medicine , chemistry , inflammation , fatty acid , biochemistry , dentistry , enzyme
Background: Polyunsaturated fatty acids have the potential to attenuate inflammation by the synthesis of mediators of the 15‐lipoxygenase pathways, which show opposite effects to the pro‐inflammatory arachidonic acid metabolites such as leukotriene B 4 (LTB 4 ). Aims: The aim of this clinical study was to evaluate the effects of topical application of n −6 or n −6 polyunsaturated fatty acids in patients with experimental gingivitis. Methods: In each subject, similar teeth served as experimental and control over a 21‐day non‐hygiene phase and a 9‐day resolving phase. Efficacy assessment was based on the bleeding on probing frequency (BOP) and the gingivocrevicular fluid volume (GCF). GCF was determined by inserting a filter paper strip for 30 s and measurements were performed on a Periotron 8000. The LTB 4 concentration was analyzed by reversed‐phase high‐pressure liquid chromatography. Results: After 21 days of plaque growth, the BOP, GCF and LTB 4 levels were significantly increased in all groups, with no differences between the control and experimental side. Rinsing of an area with established gingivitis for a 9‐day period significantly reduced the GCF in the n −6 group (71.9 (18.7) versus 47.4 (11.4) Periotron Units, median (inter quartile range)). Conclusion: The topical application of n −6 or n −6 fatty acids failed to inhibit the development of experimental gingivitis. Rinsing with n −6 fatty acids could reduce the level of GCF in established experimental gingivitis.