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Effet d'un bain de bouche au fluor d'amine et au triclosan sur la croissance de la plaque dentaire et la vitalité du biofilm
Author(s) -
Arweiler Nicole B.,
Henning G.,
Reich E.,
Netuschil L.
Publication year - 2002
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.2002.290412.x
Subject(s) - triclosan , placebo , fluoride , chlorhexidine , crossover study , biofilm , medicine , sodium fluoride , dentistry , dental plaque , nuclear chemistry , chemistry , bacteria , pathology , biology , inorganic chemistry , alternative medicine , genetics
Background: The purpose of this double‐blind, prospective, latin‐square crossover randomised study was to examine the efficacy of a mouthrinse solution containing a combination of triclosan, amine fluoride and sodium fluoride on supragingival plaque regrowth compared to a placebo and a chlorhexidine solution. Methods: 12 volunteers refrained after professional oral prophylaxis from all mechanical hygiene measures for the following 96 h and rinsed instead cross‐over in a randomised order with either chlorhexidine dicluconate (0.2%, positive control), a verum solution (0.5% amine fluoride, 0.028% sodium fluoride, 0.03% triclosan) or a placebo solution. The plaque index was assessed after 24 and 96 h (PI 1, PI 2) and the plaque area (PA) photographed and calculated after 96 h of undisturbed plaque regrowth. Moreover plaque samples were taken after 24 and 96 h and examined with the vital fluorescence technique to assess the vitality of the biofilm microbiota (VF 1, VF 2). Results: The amine‐fluoride‐triclosan solution reduced the clinical parameters (PI and PA) as well as the vitality of the plaque flora (VF) significantly when compared to the placebo solution. The verum reached a 36.5% ( p <0.05) and a 39.8% reduction ( p <0.0001) in PI 1 and PI 2, respectively, concomittant with a reduction of 23.8% and 32.2% ( p <0.001) in VF 1 and VF 2 and of 46.9% ( p <0.0001) in PA at day 4. This was less than the reductions found with the positive control, i.e., the 0.2% chlorhexidine solution (54.2% and 71.1% reduction in PI 1 and PI 2, 40.0% and 53.4% in VF 1 and VF 2 and 71.5% in PA). However, significant differences between both active solutions were only established for PI 2 and PA. Conclusion: During 4‐day plaque regrowth the amine‐fluoride‐triclosan product displayed a significant antibacterial and plaque‐reducing action in comparison to the control.