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5 polymorphismes dans le gène facteur β 1 de croissance transformant dans la parodontite de l'adulte
Author(s) -
Holla Lydie Izakovicova,
Fassmann Antonin,
Benes Petr,
Halabala Tomas,
Znojil Vladimir
Publication year - 2002
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.2002.290409.x
Subject(s) - periodontitis , genotype , allele , transforming growth factor , polymorphism (computer science) , transforming growth factor beta , gene polymorphism , biology , medicine , gene , immunology , genetics
Objectives: Transforming growth factor–β (TGF‐beta) represents a family of polypeptide growth factors, involved in inflammation and regulation of immune responses. The purpose of this study was to determine whether polymorphisms in the TGF‐beta 1 gene may confer susceptibility to adult periodontitis. Material and methods: We studied 90 patients with adult periodontitis together with 108 unrelated subjects. 3 polymorphisms located in the 5′region at positions −988 (C/A), −800 (G/A) and −509 (C/T) and 2 polymorphisms located at codons 10 (L10P) and 25 (R25P) of exon 1 were investigated by PCR methods. Results: There was no statistically‐significant difference in genotype or allele frequency distributions between patients and reference group for the −800G/A, −509C/T, L10P and R25P polymorphisms ( p >0.05 in all cases). The −988 A polymorphism was present neither in our patients nor in unrelated subjects. Upon stratification for smoking status no significant differences were found in the TGF‐β 1 genotype or allele frequencies either between adult periodontitis smokers compared to control smokers, or between periodontitis non‐smokers and control non‐smokers. Conclusion: These data indicate that the mentioned polymorphisms of the TGF‐β 1 gene do not influence susceptibility to adult periodontitis. There was no association between any polymorphisms in the TGF‐beta 1 gene, severity of periodontitis and the smoking status in our study.