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Étude de l’infiltrat inflammatoire gingival chez des malades cardiaques traités par inhibiteurs calciques
Author(s) -
Bullón Pedro,
Machuca Guillermo,
Armas José R.,
Rojas José L.,
Jiménez Gema
Publication year - 2001
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1034/j.1600-051x.2001.028010897.x
Subject(s) - medicine , nifedipine , analysis of variance , diltiazem , one way analysis of variance , gastroenterology , calcium
Objectives: To analyse the periodontal inflammatory infiltrates in patients with cardiac disease, some of these patients were treated with calcium antagonists (nifedipine and diltiazem) and some were not, to compare them with a healthy control group, and to evaluate the changes in the inflammatory infiltrate after periodontal treatment. Material and methods: A “healthy group” (HG, n =12), a “cardiac group” (CG, n =12) without treatment with calcium antagonists, a “nifedipine group” (NG, n =18) and a “diltiazem group” (DG, n =13) were analysed. Biopsies were taken from a zone 2–3 mm below the upper part of the interproximal papillae 12–13 and 33–32 before causal periodontal treatment and after 1 year. Using haematoxylin‐eosin staining, the plasma cells (P), lymphocytes (L), histiocytes (H) and polymorphonuclear cells (PMN) were counted. T and B lymphocytes were evaluated using the monoclonal antibodies anti‐CD20 and anti‐CD45RO. Statistical tests used: χ 2 for study of the sample composition; ANOVA for comparison between groups; Student t ‐test and Wilcoxon test for comparison between visits; post‐hoc test Bonferroni. Results: When the cells were compared statistically, differences were stablished for L at the first visit ( p <0.00001) and at the last visit ( p <0.02), for the B lymphocytes (first visit p <0.0021, last visit p <0.022) and for the T lymphocytes (first visit p <0.0042, last visit p <0.0021). Between the 2 visits, HG showed significant reductions for P ( p <0.01), L ( p <0.045) and H ( p <0.033); and the NG for L ( p <0.0001). Lymphocytes showed differences in the NG with respect to the B lymphocytes ( p <0.008). Conclusions: Nifedipine affects the inflammatory infiltrate with a greater number of lymphocytes (especially B) and these cells fell significantly in number after periodontal treatment.